Panorama

Includes screening for:

Trisomy 21, 18 and 13 (including Down’s Syndrome).

X and Y (sex chromosome abnormalities including Turner – can only be tested if there is a single fetus or monozygotic twins and if it is not egg donation).

Triploidy (an extra set of chromosomes that causes organ defects, a high incidence of spontaneous abortion and short life span. Can not be tested if there are twins or if it is egg donation).

DiGeorge/2211q.2 (heart defects, immune system problems, special facial features). Can only be tested if there is a single fetus or monozygotic twins and if it is not egg donation. Screening for 2211q.2 can be opted out if desired. The price is the same.

Gender (optional). Available for singletons and monozygotic twins (not egg donation).

Not available for twins or egg donation

Includes screening for:

Trisomy 21, 18 and 13 (including Down’s Syndrome).

X and Y (sex chromosome abnormalities, including Turner).

Triploidy (an extra set of chromosomes that causes organ defects, a high incidence of spontaneous abortion and short lifespan).

DiGeorge/2211q.2 (heart defects, immune system problems, distinctive facial features).

Prader-Willi (growth problems, developmental delay, obesity)

Angelmann (severe developmental delay, epilepsy, balance problems)

1p36 (developmental delay, epilepsy),

Cri-du-chat (moderate to severe developmental delay, sometimes malformations).

Gender optional.

Panorama is a Non Invasive Prenatal Test (NIPT), which can be taken from week 9. It screens for chromosomal abnormalities with high precision – without the risk to the fetus that is associated with invasive tests (placenta biopsy or amniocentesis).

In the blood of a pregnant woman, small amounts of DNA from the placenta are found – called ‘cell-free fetal DNA’ (cff-DNA). This DNA reflects the child’s genetic profile and mixes with the mother’s own DNA in the bloodstream.

In an NIPT test, this DNA mixture is analyzed via a regular blood sample from the mother’s arm. The test assesses the likelihood that the child has certain chromosomal abnormalities – completely without risk to the fetus.

Panorama is the only NIPT test that can screen for triploidy.

Important to know:

Panorama is not a diagnostic test, but a very accurate risk assessment.

The accuracy of the test depends, among other things, on the fetal fraction – that is, how much of the blood DNA comes from the placenta. 

If the test shows an increased risk of chromosomal abnormalities, there is an indication for invasive testing (amniocentesis or placental biopsy).

• The entire process takes approx. 30 minutes
• Includes: A scan, scan report, color photo of your baby + all photos and video clips via Tricefy (extra color photos can be purchased (DKK 20/each)
• Signing of consent (example sent to you via email upon booking)
• Genetic guidance and in depth explanation of how the test works
• A blood sample is taken from your arm
• Turnaround time: Up to 10 business days. We will contact you when your results are ready
• If the test cannot be performed due to the condition of the fetus – or if you change your mind during the consultation – the price for an Early scan (DKK 500) will be paid. No discount is given in these cases.

⚠️ Please note: In rare cases, the laboratory may take longer to analyze – this does not necessarily mean that something is wrong.

You can have a Panorama test if you can say yes to one or more of these criteria:

• You are between 9 and 40 weeks pregnant
• You are expecting one or two babies
• You have a history of pregnancy with trisomy
• Fetal ultrasonographic findings indicating an increased risk of aneuploidy or you are not comfortable with the results of your first trimester scan
• You have received IVF Treatment or have previously suffered from habitual abortion
• Contraindications for invasive prenatal testing, such as placenta previa, risk of miscarriage or HBV infection
• You just want the extra security

You are not a candidate for Panorama if:

• You are less than 9 weeks pregnant
• You or the fetus have a known mosaicism (mixture of normal and abnormal chromosomes in the mother, fetus or placenta)
• There is a known balanced or unbalanced translocation on your chromosomes
• You have been given organ transplantation
• You have received stem cell therapy
• You have experienced “Vanishing Twin” 
• You are expecting triplets or more
• You are expecting twins by egg donor or surrogate pregnancy

Panorama is the only NIPT that can distinguish between each twin’s DNA, which means we can tell you:

Whether your twins are identical (monozygotic) or dizygotic (dizygotic).

The sex of each twin.

If the screening shows monozygotic twins, Panorama can also test for:

Turner
Sex chromosome trisomies

DiGeorge/22q11.2

Important to know:

There are limitations to what we can test for when there are twins. See details in the ‘Panorama 1’ box and in the glossary further down the page.

Panorama provides a significantly more accurate risk assessment than traditional screening methods. With over 99% sensitivity for trisomy 21, 13, triploidy and gender – and 98.2% for trisomy 18 – the need for unnecessary invasive procedures such as placental biopsy and amniocentesis is reduced. Only in cases of high risk – or when there are visual anomalies during the scan – is further testing recommended.

Panorama has determined gender with 100% certainty in over 14,000 pregnancies (read the article).

New: Panorama AI
Based on over 2 million tests, Natera has developed Panorama AI, which combines SNP technology with artificial intelligence. It provides even more accurate results – especially in difficult cases – and reduces the number of tests with no answer. The detection of 22q11.2 (DiGeorge) has also been improved.

In rare cases, there is not enough DNA in the blood sample to analyze. In this case, you will be offered a new blood sample at no extra cost, but the response time will be extended. If you do not wish to repeat the test, the price of the test will not be refunded.

If the analysis still cannot be performed after a new test, the price of the test will be refunded minus DKK 1,000 for scanning and counseling.

If the fetal fraction is below 7%, the test cannot screen for for Angelman syndrome. In these cases the background risk will remain unchanged from the background risk. This does not give rise to reimbursement.

Atypical findings: In rare cases, the analysis may show signs of unexpected chromosome variants, which make it impossible to provide an answer to certain syndromes or  fetal sex. In these cases, further genetic counseling or invasive testing isindicated. Since the test has identified a relevant risk in such cases, no reimbursement is given.

• Aneuploidy: An aberration in the chromosome set (karyotype) in the form of too many or too few chromosomes. Normally we have 46 chromosomes in our cells – 23 from the mother and 23 from the father. These are arranged in pairs. The chromosomes consist of DNA and determine – among other things – our appearance and gender (XX for girl and XY for boy). In aneuploidies, the number of chromosomes is altered (e.g. 45 or 47). The consequence of the aneuploidy depends on which chromosome pair is affected. Examples of aneuploidies are Down’s Syndrome and Turner’s Syndrome.
• Trisomy 21, Down’s Syndrome – an additional chromosome 21, i.e. 3 where there should have been 2 (tri = 3). One of the most common forms of developmental impairment.
• Trisomy 18, Edward’s syndrome – an additional 18th chromosome. Malformations and severe mental retardation. Short lifespan. Rare.
• Trisomy 13, Pataus syndrome – an additional 13th chromosome. Malformations and severe mental retardation. Short lifespan. Rare.
• Turner’s Syndrome – missing or altered sex chromosome (X) in girls.
• Triploidy – an extra set of chromosomes causing organ malformation, a high incidence of miscarriage and short lifespan.
• Microdeletions – Microdeletions are caused when a chromosome is missing a small piece. The severity of problems caused by a microdeletion is determined primarily by the size and location of the deletion.
• Placenta biopsy (Chorion Villus Sample (CVS)* – invasive test where small pieces of the placenta are retrieved through a thin needle in the mother’s abdomen for chromosome analysis. Possible from week 10.
• Amniocentesis (AC)* – invasive test where amniotic fluid is retrieved through a thin needle in the mother’s abdomen for chromosome analysis. Possible from week 16.
• Twins – Monozygotic: Identical, from the same egg. Dizygotic: Fraternal, from two seperate eggs. Monochorionic: Share the same placenta, always monozygotic. Dichorionic: Have each their own placenta. Usually dizygotic, but can be monozygotic.
• Mosaicism: A condition where a portion of cells in the placenta, the fetus or both have chromosome changes